In-Vitro Dissolution Study and Shelf Life Calculation of Developed Sol-To-Gel Ocular Drug Delivery System of Brimonidine for Conjunctivitis during Accelerated Stability Study.

The present research work deals with the in- vitro dissolution study of developed sol to gel ocular drug delivery system of brimonidine for conjunctivitis during accelerated stability study. The formulation of brimonidine was developed and optimized formulation coded as X4Y2D containing optimized amount of sodium alginate and HPMC K100LvP was evaluated for the physico-chemical characterization and drug release initially and during accelerated stability study. The drug release was determined using fabricated continuous flow through cell apparatus. The difference between initial drug release and after three month drug release was 2.606% and the calculation was done for shelf life and found 2 years.